Meta-disc a software for meta-analysis of test accuracy data

A meta analysis was performed to evaluate the diagnostic accuracy of genetic markers for the detection of leptospira in clinical samples. Meta disc software was used to obtain pooled sensitivity and specificity of the diagnostic methods. We extracted data on the study design, population, sample size, and the data used to calculate test characteristics true positives, false positives, false negatives, and true. We conducted this study according to the recommendations of the cochrane collaboration diagnostic test accuracy working group. The diagnostic accuracy of a pointofcare ultrasound. Metadisc 7 is a freeware software developed by a group of statisticians in. Diagnostic accuracy and safety of semirigid thoracoscopy in. A systematic search of databases was performed for publications. We extracted data on the study design, population, sample size, and the data used to calculate test characteristics true positives, false positives, false negatives, and true negatives.

Currently, there is a macro avaibale for sas and a package for stata. Metaanalysis of diagnostic accuracy of neutrophil cd64 for. The accuracy of vq spect in the diagnosis of pulmonary. Meta analysis is a twostage process involving the estimation of an appropriate summary statistic for each of a set of studies, followed by the. Nov 15, 2016 statistical analyses were performed using meta disc 1. Exposed bone or probetobone test had a sensitivity of 0. Pooled sensitivity and specificity, the summary measure of accuracy q, and diagnostic odds ratio were calculated.

In recent years, studies on the diagnostic accuracy of inhouse realtime pcr hrtpcr assay for the detection of mycobacterium tuberculosis mtb have been reported with unignorable discrepancies. Therefore, metaanalyses of the diagnostic test accuracy need to deal with two. Researchers have prepared macros or modules for statistical models for meta analysis of data from diagnostic test accuracy studies for several statistical analysis software programs. Doaj is an online directory that indexes and provides access to quality open access, peer.

If the studies are reasonably homogeneous, the accuracy estimates from individual studies will lie along a line corresponding to the pooled accuracy estimate. Metadisc allows users to test for heterogeneity amongst various studies in two different ways. Unfortunately, metadisc has no capacity to perform hierarchic methods. Diagnostic accuracy of ct angiography and ct perfusion for. Metaanalysis of diagnostic accuracy of neutrophil cd64. Unfortunately, meta disc has no capacity to perform hierarchic methods. Sep 18, 2012 we performed data analysis using the meta. Meta disc provides a bunch of analyses, but not all of them are suitable for meta analysis of test accuracy studies. Metadisc has a graphical user interface with rolldown. Metadisc is a comprehensive and dedicated test accuracy metaanalysis software. Overall metadisc is free for all users and easy to learn and use. The meta disc software was used to implement the meta analysis, and sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio with their 95% confidence intervals cis were used as the effect size. This metaanalysis showed that the diagnostic performance of ncd64 for neonatal sepsis was not good, because the pooled sensitivity and specificity are not high enough. Magnetocardiography for the diagnosis of coronary artery.

Metadisc is freeware software to perform metaanalysis of studies of evaluations of. Zamora j, abraira v, muriel a, khan k, coomarasamy ametadisc. It has already been used and cited in several metaanalyses published in highranking journals. Diagnostic accuracy of stress myocardial perfusion imaging. In recent years, the role of cta and ctp for vasospasm diagnosis in the setting of asah has been the subject of many research studies. I have used first meta disc, but only for descriptive purposes, as it is clear that univariate approaches such as those provided by this package are biased eg takwoingi et al. Metadisc has a graphical user interface with rolldown menus, dialog boxes, and online help facilities. The accuracy of vq spect in the diagnosis of pulmonary embolism. In this article, we present meta disc, a windowsbased, userfriendly, freely available for academic use software that we have developed, piloted, and. The area under the curve auc of the sroc was calculated and proposed as a means to assess diagnostic data in the context of metaanalysis. Diagnostic accuracy of efast in the trauma patient. Overview of the process of conducting metaanalyses of the.

Diagnostic accuracy of inhouse realtime pcr assay for. The moseslittenberg metaanalytical method generates systematic. Metaanalyses of diagnostic accuracy in imaging journals rsna. Metaanalysis of diagnostic test accuracy studies differs from the usual. Which is the best method for metaanalysis of diagnostic test. Information about the openaccess article meta disc.

Diagnostic accuracy of the 14 curea breath test in. This list is generated based on data provided by crossref. Population characteristics table i in the data supplement, imaging protocols table ii in the data supplement, reference test characteristics including preselection criteria for ffr evaluation table iii. The program has been developed by the unit of clinical biostatistics team of the ramon y cajal hospital in madrid spain. Overall meta disc is free for all users and easy to learn and use.

Pooled results indicated that the 14curea breath test showed a diagnostic sensitivity of 0. Noninvasive fetal sex determination using cellfree fetal. Herein we present a new program for the microsoft windows operating system, metaanalyst, and report on its testing versus other widely used and accepted software. In this article, we present meta disc, a windowsbased, userfriendly, freely available for academic use software that we have developed, piloted, and validated to perform diagnostic meta analysis. Meta disc is a comprehensive and dedicated test accuracy meta analysis software.

Unlike other dedicated meta analysis packages, meta analyst integrates the capabilities to perform meta analyses of binary or continuous outcomes and diagnostic or prognostic tests, combining the functionality of software such as mix and meta disc. The sensitivity, specificity, and other measures of accuracy of opn in the diagnosis of hcc were pooled using random effects models. The metaanalyses were performed by the use of metadisc software version 1. All data analyses were conducted using statistical software metadisc version 1.

Diagnostic accuracy of the physical examination and imaging. Kraus, caryn scoville, daniel theodoro, vu huy tran, george ubinas, christopher raio. The metadisc software was used to implement the metaanalysis, and sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio with their 95% confidence intervals. Metaanalyses of diagnostic accuracy in imaging journals. In this article, we present metadisc, a windowsbased, userfriendly, freely available. To compare metaanalyses of diagnostic test accuracy using the. Zamora j, abraira v, muriel a, khan ks, coomarasamy a. Zamora j, abraira v, muriel a, khan k, coomarasamy ameta disc.

All computational algorithms have been validated through comparison with different statistical tools and published metaanalyses. Pooled results indicated that the 14curea breath test showed a. Objective its difficult to differentiate sepsis from nonsepsis, especially noninfectious sirs, because no good standard exists for proof of infection. Bivariate metaanalysis of sensitivity and specificity of.

All computational algorithms in it have been validated through comparison with different statistical tools and published metaanalyses. Nine studies, comprising a total sample size of 3454 patients, were included in our metaanalysis. Metaanalysis is usually performed using computer programs. Pdf zamora j, abraira v, muriel a, khan k, coomarasamy. It has already been used and cited in several metaanalyses. Diagnostic accuracy and safety of semirigid thoracoscopy. The methodological quality of each study was assessed by quadas quality assessment for studies of diagnostic accuracy. Metadisc provides a bunch of analyses, but not all of them are suitable for metaanalysis of test accuracy studies.

Accuracy of realtime shear wave elastography in staging. This study was conducted to evaluate the diagnostic value of realtime shear wave elastography swe in the assessment of hepatic fibrosis. Diagnostic accuracy of midkine for hepatocellular carcinoma. Nitrate reductase assay for rapid detection of isoniazid. Conclusion meta disc is a comprehensive and dedicated test accuracy meta analysis software. It used to be available for download from the groups website, and now the new version metadisc 2. Meta disc is free for all users and easy to learn and use. Disc is freeware software to perform metaanalysis of. The methodological quality of each study was assessed by quadas.

The high diagnostic accuracy of multidetector ct shown in this metaanalysis and in several other reports supports the switch from catheter angiography to multidetector ct as the firstline imaging method in. Ideally, an analytic method used for this type of metaanalysis should estimate diagnostic accuracy with the least bias, incorporating various factors known to affect the results. Methodology and principle findings a literature search was performed in scopus, pubmed, medline and nonindexed citations via ovid by using suitable keyword combinations. All data analyses were conducted using statistical software meta disc version 1. The statistical software packages metadisc version 1. Pdf recommended softwarepackages for metaanalysis of. Accuracy of computed tomographic enterography for obscure. Reliability and validity of different mri sequences in.

Sensitivity, specificity, likelihood ratio lr and diagnostic odds ratio dor were used. Bivariate metaanalysis of sensitivity and specificity with sparse data. This metaanalysis aims to evaluate the diagnostic accuracy of lung auscultation for the most common respiratory pathologies. Data was extracted by one author and verified by another author for accuracy. The diagnostic accuracy of a pointofcare ultrasound protocol for shock etiology. Research article open access metaanalysis to compare the. Metadisc is a freeware software developed by a group of statisticians in spain to perform metaanalysis of diagnostic and screening tests. Last but not least, metadisc provides a bunch of analyses, but not all of them are suitable for metaanalysis of test accuracy. The pooled sensitivity, specificity of vq spect in the diagnosis of acute pe patients, calculated on a perpatientbased analysis, was 96% 95% confidence interval ci, 9597%, 97% 95% ci, 9698%. Meta disc has a graphical user interface with rolldown menus, dialog boxes, and online help facilities. Reviewed by javier zamora, 1 victor abraira, 1 alfonso muriel, 1 khalid khan, 2 and arri coomarasamy 2. Statistical analysis was performed by employing meta disc 1. The identified studies were analyzed using meta disc 1. Recommended softwarepackages for metaanalysis of diagnostic.

Metaanalysis to compare the accuracy of genexpert, mods. The diagnostic accuracy of lung auscultation in adult. Clinical epidemiology program, ottawa hospital research. Unlike other dedicated metaanalysis packages, metaanalyst integrates the capabilities to perform metaanalyses of binary or continuous.

Jul 12, 2006 all computational algorithms have been validated through comparison with different statistical tools and published meta analyses. Combining independent studies of a diagnostic test into a summary roc curve. Zamora j, abraira v, muriel a, khan k, coomarasamy a. I am conducting a meta analysis of diagnostic test accuracy studies focusing on myocardial perfusion imaging. Aug 15, 2008 we undertook a meta analysis of the accuracy of diagnostic tests for osteomyelitis in diabetic patients with foot ulcers. Diagnostic accuracy of multidetector ct in acute mesenteric. Statistical analyses were performed using metadisc 1. May 21, 20 meta analysis of prognostic test accuracy. Accuracy of transvaginal sonography versus magnetic resonance. The high diagnostic accuracy of multidetector ct shown in this meta analysis and in several other reports supports the switch from catheter angiography to multidetector ct as the firstline imaging method in patients suspected of having primary ami. Comparison osteopontin vs afp for the diagnosis of hcc. Studies concerning adult patients with respiratory symptoms are included. However, just as the authors stated, the current version of meta disc uses outdated statistical methods and should not be used for making inferences. Statsdirect ltd were used to perform all the statistical analysis.

All computational algorithms have been validated through comparison with different statistical tools and published meta analyses. Although a meta analysis on this subject has been recently published, it followed a distinct methodology and selection criteria for included studies, with a smaller number of patients and lower pre test probability, therefore justifying the addition of a different meta analysis on this theme to the literature. Metaanalysis is a twostage process involving the estimation of an appropriate summary statistic for each of a set of studies, followed by the. Last but not least, meta disc provides a bunch of analyses, but not all of them are suitable for meta analysis of test accuracy studies.

Diagnostic accuracy of rating scales for attentiondeficit. Metaanalysis of diagnostic test accuracy studies is a useful method to increase the level of validity by combining data from multiple studies. Data from primary studies, including study id, accuracy data tp, fp, tn. Data from primary studies, including study id, accuracy. Sensitivity, specificity, likelihood ratio lr and diagnostic odds ratio dor were used as measures of the diagnostic accuracy of nbi and wli in characterizing bladder cancer, including cis. I am conducting a metaanalysis of diagnostic test accuracy studies focusing on myocardial perfusion imaging. This meta analysis showed that the diagnostic performance of ncd64 for neonatal sepsis was not good, because the pooled sensitivity and specificity are not high enough. The pooled sensitivities were 96% for inh, 97% for rif, 90% for emb, and 82% for str. The hierarchical models preserve the bivariate nature of test accuracy data in terms of both.

As these become available we will add them to this page. Diagnostic accuracy of transvaginal ultrasound for non. Although the auc is relatively high, the application of ncd64 for diagnosing neonatal sepsis needs to be cautious. A systematic search of databases was performed for publications on swe during the period between 2010 and 2017. However, there is currently no dedicated and comprehensive software for meta analysis of diagnostic data. The submetaanalysis evaluating four studies for hba1c of 6. A reason for the relatively poor adoption of recommended methods for meta analysis of diagnostic accuracy data could be a general lack of guidance. However, there is currently no dedicated and comprehensive software for metaanalysis of diagnostic data. Diagnostic accuracy of genetic markers and nucleic acid. Metadisc has a graphical user interface with rolldown menus, dialog. Diagnostic accuracy of glycated hemoglobin for post. The sub meta analysis evaluating four studies for hba1c of 6. Ying kan, leilei yuan, jacqui k meeks, chunlin li, wencao liu, and jigang yang. Objective to document overall test performance of noninvasive fetal sex determination using cellfree fetal dna and to identify variables that affect performance.